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| Linear Monofunctional PEG Derivatives Linear monofunctional PEG derivatives have a reactive group at one end of the PEG and the other end is capped with a methoxy group or a sugar group. Linear monofunctional PEG derivatives have the following general structure: CAP―PEG―X where X is the functional group or active group and CAP can be either a methoxy group or a sugar molecule
List of Linear Monofunctional PEG Derivatives:
GLUC-NHS-35K: Glucose PEG NHS Ester2 GALA-NHS-35K: Glucose PEG NHS Ester2 M-PEG-SCM: Methoxy PEG Succinimidyl Carboxymethyl Ester3 M-COOH-PEG: Methoxy PEG Carboxyl6 M-PEG-SC: Methoxy PEG Succinimidyl Carbonate3 M-PEG-NPC: Methoxy PEG Nitrophenyl Carbonate4 M-PEG-SS: Methoxy PEG Succinimidyl Succinate4 M-PEG-SG: Methoxy PEG Succinimidyl Glutarate4 M-PEG-MAL: Methoxy PEG Maleimide4 M-PEG-VS: Methoxy PEG Vinylsulfone5 M-PEG-SH: Methoxy PEG Thiol5 M-PEG-ALD: Methoxy PEG Propionaldehyde6 M-NH2-PEG: Methoxy PEG Amine, HCl Salt6 M-HZ-PEG: Methoxy PEG Hydrazide7 M-AZIDE-PEG: Methoxy PEG Azide7 M-BIOTIN-PEG: Methoxy PEG Biotin7 M-ACLT-PEG: Methoxy PEG Acrylate8 M-SLN-PEG: Methoxy PEG Silane8
For Amine PEGylation
JenKem Technology offers the following linear PEG NHS esters as regular products to meet with your different PEGylation requirements. Other PEG NHS esters with different molecular weights are available through custom synthesis. The N-hydroxysuccinimide ester (or NHS ester) ester in this product will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a stable amide linkage(s). The presence of glucose group will increase the selectivity of the PEGylation reaction. Glucose PEG NHS Ester will couple to the targeted molecules at pH 7-8. The PEGylation reaction can be finished in about 1 hour at ambient temperature. The NHS ester in this product is Succinimidyl Carboxymethyl Ester.
The average molecular weight of JenKem's Glucose PEG NHS Ester is 35,000 Da. Substitution is 90% or greater. This product is basically free of active difunctional PEG impurities. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A2001-1 | GLUC-NHS-35K,1g | Glucose PEG NHS Ester, MW 35000 | $150 | A2001-10 | GLUC-NHS-35K,10g | Glucose PEG NHS Ester, MW 35000 | $1200 |
GALA-NHS-35K: Glucose PEG NHS Ester, MW 35000 The N-hydroxysuccinimide ester (or NHS ester) ester in this product will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a stable amide linkage(s). The presence of Galactose group will increase the selectivity of the PEGylation reaction. Galactose PEG NHS Ester will couple to the targeted molecules at pH 7-8. The PEGylation reaction can be finished in about 1 hour at ambient temperature. The NHS ester in this product is Succinimidyl Carboxymethyl Ester.
The average molecular weight of JenKem's Galactose PEG NHS Ester is 35,000 Da. Substitution is 90% or greater. This product is basically free of active difunctional PEG impurities. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A2002-1 | GALA-NHS-35K,1g | Galactose PEG NHS Ester, MW 35000 | $200 | A2002-10 | GALA-NHS-35K,10g | Galactose PEG NHS Ester, MW 35000 | $1600 |
The Succinimidyl Carboxymethyl Ester (NHS ester) will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a stable amide linkage(s). M-PEG-SCM will couple with the targeted molecules at pH 7-8. The PEGylation reaction can be finished in about 1 hour at ambient temperature. The substitution of M-SCM-20K is 95% or greater. M-PEG-SCM is basically free of active difunctional PEG impurities. Other molecular weights including molecular weight up to 80kDa is available through custom synthesis. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3072-1 | M-SCM-2000,1g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 2000 | $80 | A3072-10 | M-SCM-2000,10g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 2000 | $640 | A3012-1 | M-SCM-5000,1g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 5000 | $80 | A3012-10 | M-SCM-5000,10g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 5000 | $640 | A3016-1 | M-SCM-10K,1g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 10000 | $80 | A3016-10 | M-SCM-10K,10g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 10000 | $640 | A3003-1 | M-SCM-20K,1g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 20000 | $80 | A3003-10 | M-SCM-20K,10g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 20000 | $640 | A3004-1 | M-SCM-30K,1g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 30000 | $110 | A3004-10 | M-SCM-30K,10g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 30000 | $880 | A3005-1 | M-SCM-35K,1g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 35000 | $110 | A3005-10 | M-SCM-35K,10g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 35000 | $880 | A3041-1 | M-SCM-40K,1g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 40000 | $130 | A3041-10 | M-SCM-40K,10g | Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 40000 | $1040 |
Methoxy PEG Carboxyl is the precursor to make Methoxy PEG Succinimidyl Carboxymethyl Ester (M-PEG-SCM). Methoxy PEG Carboxyl is much stable compared with M-PEG-SCM and can be used similarly to the corresponding NHS ester. M-PEG-SCM is chromatographically purified and is basically free of difunctional PEG impurities. The purity of M-COOH-PEG is 95% or greater. ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3070-1 | M-COOH-5000,1g | Methoxy PEG Carboxyl, MW 5000 | $70 | A3070-10 | M-COOH-5000,10g | Methoxy PEG Carboxyl, MW 5000 | $560 | A3081-1 | M-COOH-10K,1g | Methoxy PEG Carboxyl, MW 10000 | $70 | A3081-10 | M-COOH-10K,10g | Methoxy PEG Carboxyl, MW 10000 | $560 | A3089-1 | M-COOH-20K,1g | Methoxy PEG Carboxyl, MW 20000 | $70 | A3089-10 | M-COOH-20K,10g | Methoxy PEG Carboxyl, MW 20000 | $560 |
M-PEG-SC: Methoxy PEG Succinimidyl Carbonate, MW 10000, MW 12000, MW 20000
The Succinimidyl Carbonate group (NHS ester) in M-PEG-SC will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a urethane linkage. Urethane linker is also a stable linker but it is not as stable as amide linker. The hydrolysis half life of M-PEG-SC is longer than the hydrolysis half life of M-PEG-SCM. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3083-1 | M-SC-10K,1g | Methoxy PEG Succinimidyl Carbonate, MW 10000 | $80 | A3083-10 | M-SC-10K,10g | Methoxy PEG Succinimidyl Carbonate, MW 10000 | $640 | A3061-1 | M-SC-12K,1g | Methoxy PEG Succinimidyl Carbonate, MW 12000 | $80 | A3061-10 | M-SC-12K,10g | Methoxy PEG Succinimidyl Carbonate, MW 12000 | $640 | A3021-1 | M-SC-20K,1g | Methoxy PEG Succinimidyl Carbonate, MW 20000 | $80 | A3021-10 | M-SC-20K,10g | Methoxy PEG Succinimidyl Carbonate, MW 20000 | $640 |
M-PEG-NPC: Methoxy PEG Nitrophenyl Carbonate, MW 10000, MW 20000 The Nitrophenyl Carbonate group (NHS ester) in M-PEG-NPC will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a urethane linkage. Urethane linker is also a stable linker but it is not as stable as amide linker. The reaction between M-PEG-NPC and amine containing molecules will release a p-nitrophenol which can be easily followed by UV spectroscopy. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3094-1 | M-NPC-10K,1g | Methoxy PEG Nitrophenyl Carbonate, MW 10000 | $80 | A3094-10 | M-NPC-10K,10g | Methoxy PEG Nitrophenyl Carbonate, MW 10000 | $640 | A3038-1 | M-NPC-20K,1g | Methoxy PEG Nitrophenyl Carbonate, MW 20000 | $80 | A3038-10 | M-NPC-20K,10g | Methoxy PEG Nitrophenyl Carbonate, MW 20000 | $640 |
The Succinimidyl Succinate group (NHS ester) in M-PEG-SS will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a urethane linkage. Urethane linker is also a stable linker but it is not as stable as amide linker. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3011-1 | M-SS-5000,1g | Methoxy PEG Succinimidyl Succinate, MW 5000 | $80 | A3011-10 | M-SS-5000,10g | Methoxy PEG Succinimidyl Succinate, MW 5000 | $640 | A3022-1 | M-SS-20K,1g | Methoxy PEG Succinimidyl Succinate, MW 20000 | $80 | A3022-10 | M-SS-20K,10g | Methoxy PEG Succinimidyl Succinate, MW 20000 | $640 |
M-PEG-SG: Methoxy PEG Succinimidyl Glutarate, MW 5000, MW 20000
The Succinimidyl Glutarate group (NHS ester) in M-PEG-SG will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a urethane linkage. Urethane linker is also a stable linker but it is not as stable as amide linker. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3101-1 | M-SG-5000,1g | Methoxy PEG Succinimidyl Glutarate, MW 5000 | $80 | A3101-10 | M-SG-5000,10g | Methoxy PEG Succinimidyl Glutarate, MW 5000 | $640 | A3031-1 | M-SG-20K,1g | Methoxy PEG Succinimidyl Glutarate, MW 20000 | $80 | A3031-10 | M-SG-20K,10g | Methoxy PEG Succinimidyl Glutarate, MW 20000 | $640 |
For Thiol PEGylation
M-PEG-MAL reacts with the thiol groups on cystein side chains in proteins and peptides to generate a stable 3-thiosuccinimidyl ether linkage. This reaction is very selective and can take place under mild conditions at about pH 5.0-6.5 in the presence of other functional groups. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3073-1 | M-MAL-2000,1g | Methoxy PEG Maleimide, MW 2000 | $120 | A3073-10 | M-MAL-2000,10g | Methoxy PEG Maleimide, MW 2000 | $960 | A3014-1 | M-MAL-5000,1g | Methoxy PEG Maleimide, MW 5000 | $120 | A3014-10 | M-MAL-5000,10g | Methoxy PEG Maleimide, MW 5000 | $960 | A3045-1 | M-MAL-10K,1g | Methoxy PEG Maleimide, MW 10000 | $120 | A3045-10 | M-MAL-10K,10g | Methoxy PEG Maleimide, MW 10000 | $960 | A3002-1 | M-MAL-20K,1g | Methoxy PEG Maleimide, MW 20000 | $120 | A3002-10 | M-MAL-20K,10g | Methoxy PEG Maleimide, MW 20000 | $960 | A3046-1 | M-MAL-30K,1g | Methoxy PEG Maleimide, MW 30000 | $130 | A3046-10 | M-MAL-30K,10g | Methoxy PEG Maleimide, MW 30000 | $1040 | A3042-1 | M-MAL-40K,1g | Methoxy PEG Maleimide, MW 40000 | $150 | A3042-10 | M-MAL-40K,10g | Methoxy PEG Maleimide, MW 40000 | $1200 |
Sulfhydryl addition to the vinylsulfone generates a stable beta-thiosulfonyl linkage. Vinylsulfone is stable in aqueous solution for a long time at high pH. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3034-1 | M-VS-5000,1g | Methoxy PEG Vinylsulfone, MW 5000 | $120 | A3034-10 | M-VS-5000,10g | Methoxy PEG Vinylsulfone, MW 5000 | $960 | A3006-1 | M-VS-20K,1g | Methoxy PEG Vinylsulfone, MW 20000 | $120 | A3006-10 | M-VS-20K,10g | Methoxy PEG Vinylsulfone, MW 20000 | $960 |
M-PEG-SH reacts with the thiol groups on Cysteine side chains in proteins and peptides to generate a disulfide-bridged polymer conjugate. This reaction can be performed under mild reaction conditions in the presence of other functional groups. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3029-1 | M-SH-5000,1g | Methoxy PEG Thiol, MW 5000 | $120 | A3029-10 | M-SH-5000,10g | Methoxy PEG Thiol, MW 5000 | $960 | A3007-1 | M-SH-20K,1g | Methoxy PEG Thiol, MW 20000 | $120 | A3007-10 | M-SH-20K,10g | Methoxy PEG Thiol, MW 20000 | $960 | A3095-1 | M-SH-30K,1g | Methoxy PEG Thiol, MW 30000 | $150 | A3095-10 | M-SH-30K,10g | Methoxy PEG Thiol, MW 30000 | $1200 | A3051-1 | M-SH-40K,1g | Methoxy PEG Thiol, MW 40000 | $170 | A3051-10 | M-SH-40K,10g | Methoxy PEG Thiol, MW 40000 | $1360 |
For N-Terminal PEGylation
M-PEG-ALD preferably reacts with the N-terminal amine in biological active molecules to produce a stable amine linkage in the presence of a reducing reagent such as sodium cyanoborohydride. M-PEG-ALD will couple with the N-terminal amine of the targeted molecules at pH 5-8. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3039-1 | M-ALD-5000,1g | Methoxy PEG Propionaldehyde, MW 5000 | $100 | A3039-10 | M-ALD-5000,10g | Methoxy PEG Propionaldehyde, MW 5000 | $800 | A3001-1 | M-ALD-20K,1g | Methoxy PEG Propionaldehyde, MW 20000 | $100 | A3001-10 | M-ALD-20K,10g | Methoxy PEG Propionaldehyde, MW 20000 | $800 | A3026-1 | M-ALD-30K,1g | Methoxy PEG Propionaldehyde, MW 30000 | $120 | A3026-10 | M-ALD-30K,10g | Methoxy PEG Propionaldehyde, MW 30000 | $960 | A3053-1 | M-ALD-40K,1g | Methoxy PEG Propionaldehyde, MW 40000 | $150 | A3053-10 | M-ALD-40K,10g | Methoxy PEG Propionaldehyde, MW 40000 | $1200 |
Other Linear Methoxy PEG Derivatives
Methoxy PEG Amine is very useful activated PEG product which can attach to other molecules through a variety of stable linkages, such as amide, urethane, urea, secondary amine. The HCl salt form provides stability for the solid form of Amine.
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3071-1 | M-NH2-2000,1g | Methoxy PEG Amine, HCl Salt, MW 2000 | $50 | A3071-10 | M-NH2-2000,10g | Methoxy PEG Amine, HCl Salt, MW 2000 | $400 | A3035-1 | M-NH2-5000,1g | Methoxy PEG Amine, HCl Salt, MW 5000 | $50 | A3035-10 | M-NH2-5000,10g | Methoxy PEG Amine, HCl Salt, MW 5000 | $400 | A3052-1 | M-NH2-10K,1g | Methoxy PEG Amine, HCl Salt, MW 10000 | $50 | A3052-10 | M-NH2-10K,10g | Methoxy PEG Amine, HCl Salt, MW 10000 | $400 | A3008-1 | M-NH2-20K,1g | Methoxy PEG Amine, HCl Salt, MW 20000 | $50 | A3008-10 | M-NH2-20K,10g | Methoxy PEG Amine, HCl Salt, MW 20000 | $400 | A3043-1 | M-NH2-30K,1g | Methoxy PEG Amine, HCl Salt, MW 30000 | $60 | A3043-10 | M-NH2-30K,10g | Methoxy PEG Amine, HCl Salt, MW 30000 | $480 | A3049-1 | M-NH2-40K,1g | Methoxy PEG Amine, HCl Salt, MW 40000 | $80 | A3049-10 | M-NH2-40K,10g | Methoxy PEG Amine, HCl Salt, MW 40000 | $640 |
Methoxy PEG Hydrazide is a much weaker base compared with Methoxy PEG amine. Methoxy PEG Hydrazide can react with aldehydes or ketones to form relatively stable hydrazone linkage (pH 3-5).
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3060-1 | M-HZ-5000,1g | Methoxy PEG Hydrazide, MW 5000 | $100 | A3060-10 | M-HZ-5000,10g | Methoxy PEG Hydrazide, MW 5000 | $800 | A3096-1 | M-HZ-10K,1g | Methoxy PEG Hydrazide, MW 10000 | $100 | A3096-10 | M-HZ-10K,10g | Methoxy PEG Hydrazide, MW 10000 | $800 | A3059-1 | M-HZ-20K,1g | Methoxy PEG Hydrazide, MW 20000 | $100 | A3059-10 | M-HZ-20K,10g | Methoxy PEG Hydrazide, MW 20000 | $800 | A3065-1 | M-HZ-30K,1g | Methoxy PEG Hydrazide, MW 30000 | $110 | A3065-10 | M-HZ-30K,10g | Methoxy PEG Hydrazide, MW 30000 | $880 |
The terminal nitrogen in Methoxy PEG Azide is mildly nucleophilic. The Azide group may be reduced to amines by hydrogenolysis. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3082-1 | M-AZIDE-5000,1g | Methoxy PEG Azide, MW 5000 | $100 | A3082-10 | M-AZIDE-5000,10g | Methoxy PEG Azide, MW 5000 | $800 | A3093-1 | M-AZIDE-20K,1g | Methoxy PEG Azide, MW 20000 | $100 | A3093-10 | M-AZIDE-20K,10g | Methoxy PEG Azide, MW 20000 | $800 |
Methoxy PEG Biotin can be used to attach avidin-containing surfaces or molecules. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3097-1 | M-BIOTIN-5000,1g | Methoxy PEG Biotin, MW 5000 | $150 | A3097-10 | M-BIOTIN-5000,10g | Methoxy PEG Biotin, MW 5000 | $1200 | A3048-1 | M-BIOTIN-20K,1g | Methoxy PEG Biotin, MW 20000 | $150 | A3048-10 | M-BIOTIN-20K,10g | Methoxy PEG Biotin, MW 20000 | $1200 |
Methoxy PEG Acrylate can be used in vinyl polymerization or co-polymerization to produce graft polymers or crosslinked materials. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3098-1 | M-ACLT-5000,1g | Methoxy PEG Acrylate, MW 5000 | $80 | A3098-10 | M-ACLT-5000,10g | Methoxy PEG Acrylate, MW 5000 | $640 | A3099-1 | M-ACLT-20K,1g | Methoxy PEG Acrylate, MW 20000 | $80 | A3099-10 | M-ACLT-20K,10g | Methoxy PEG Acrylate, MW 20000 | $640 |
Methoxy PEG Silane is widely used in surface modification. 
ITEM CODE | ITEM NUMBER | ITEM DESCRIPTION | PRICE (USD) | A3037-1 | M-SLN-5000,1g | Methoxy PEG Silane, MW 5000 | $100 | A3037-10 | M-SLN-5000,10g | Methoxy PEG Silane, MW 5000 | $800 | A3100-1 | M-SLN-20K,1g | Methoxy PEG Silane, MW 20000 | $100 | A3100-10 | M-SLN-20K,10g | Methoxy PEG Silane, MW 20000 | $800 |
Please check our 2011 PEG Products Catalog 2011 JENKEM USA PEG PRODUCTS CATALOG Storage and Handling Conditions for PEGs and PEG Derivatives To order, please contact us at sales@jenkemusa.com
Other molecular weights are available.
Quotations for bulk orders are available. Prices are subject to change without notice. Shipping and Handling Fee is not included in the price. PEG Derivatives Custom Synthesis JenKem Technology has the expertise and experience on the synthesis of many kinds of special PEG derivatives. JenKem Technology can design and synthesize to meet your special needs. Please contact JenKem USA's technical support at tech@jenkemusa.com for your custom synthesis requests. | |
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