Linear Monofunctional PEG Derivatives For PEGylation
Linear monofunctional PEG derivatives have a reactive group at one end of the PEG and the other end is capped with a methoxy group or a sugar group.
Linear monofunctional PEG derivatives have the following general structure::
CAP-PEG - X
where X is the functional group or active group
and CAP can be either a methoxy group or a sugar molecule
JenKem now provides two patented high molecular weight linear monofunctional PEG derivatives, GLUC-NHS-35K and GALA-NHS-35K. They are both used for amine PEGylation.
For Amine PEGylation
JenKem Technology offers the following linear PEG NHS esters as regular products to meet with your different PEGylation requirements. Other PEG NHS esters with different molecular weights are available through custom synthesis.
GLUC-NHS-35K: Glucose PEG NHS Ester, MW 35000
This N-hydroxysuccinimide (or NHS) ester will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a stable amide linkage(s). The presence of glucose group will increase the selectivity of the PEGylation reaction. GLUC-NHS-35K will couple to the targeted molecules at pH 7-8. The PEGylation reaction can be finished in about 1 hour.
The average molecular weight of JenKem's GLUC-NHS-35K is 35,000 Da. Substitution is 90% or greater. This product is basically free of active difunctional PEG impurities.
| Item Number | Price for 1.0g | Price for 10.0g |
| GLUC-NHS-35K | $150 | $1200 |
GALA-NHS-35K: Glucose PEG NHS Ester, MW 35000
This N-hydroxysuccinimide (or NHS) ester will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a stable amide linkage(s). The presence of galactose group will increase the selectivity of the PEGylation reaction. GALA-NHS-35K will couple with the targeted molecules at pH 7-8. The PEGylation reaction can be finished in about 1 hour.
The average molecular weight of JenKem's GALA-NHS-35K is 35,000 Da. Substitution is 90% or greater. JenKem's This product is basically free of active difunctional PEG impurities.
| Item Number | Price for 1.0g | Price for 10.0g |
GALA-NHS-35K | $180 | $1440 |
M-PEG-SCM: Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 2000, MW 5000, MW 20000, MW 30000, MW 35000, MW 40000
This N-hydroxysuccinimide (or NHS) ester will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a stable amide linkage(s). This NHS ester will couple with the targeted molecules at pH 7-8. The PEGylation reaction can be finished in about 1 hour. Substitution of M-SCM-20K is 95% or greater. JenKem's M-PEG-SCM is basically free of active difunctional PEG impurities. Other molecular weights including molecular weight upto 80kDa are available through custom synthesis.
| Item Number | Price for 1.0g | Price for 10.0g |
| M-SCM-2000 | $80 | $640 |
| M-SCM-5000 | $80 | $640 |
| M-SCM-20K | $80 | $640 |
| M-SCM-30K | $110 | $880 |
| M-SCM-35K | $110 | $880 |
M-SCM-40K | $130 | $1040 |
M-PEG-SC: Methoxy PEG Succinimidyl Carbonate, MW 20000
| Item Number | Price for 1.0g | Price for 10.0g |
M-SC-20K | $80 | $640 |
M-PEG-NPC: Methoxy PEG Nitrophenyl Carbonate, MW 20000
| Item Number | Price for 1.0g | Price for 10.0g |
M-NPC-20K | $80 | $640 |
For Thiol PEGylation
M-PEG-MAL: Methoxy PEG Maleimide, MW 2000, MW 5000, MW 20000, MW 30000, MW 40000
M-PEG-MAL reacts with the thiol groups on cystein side chains in proteins and peptides to generates a stable 3-thiosuccinimidyl ether linkage. This maleimide will couple with the targeted molecules at about pH 5.0-6.5 in the presence of other functional groups. Substitution of M-PEG-MAL is 90% or greater.
| Item Number | Price for 1.0g | Price for 10.0g |
| M-MAL-2000 | $120 | $960 |
| M-MAL-5000 | $120 | $960 |
| M-MAL-20K | $120 | $960 |
| M-MAL-30K | $130 | $1040 |
M-MAL-40K | $150 | $1200 |
M-PEG-VS: Methoxy PEG Vinylsulfone, MW 5000, MW 20000
Sulfhydryl additon to the vinylsulfone generates a stabel beta-thiosulfonyl linkage. Vinylsulfone is stable in aqueous solution for a long time at high pH. Substitution of M-PEG-VS is 90% or greater. Purity of M-VS-PEG is 95% or greater.
Item Number | Price for 1.0g | Price for 10.0g |
| M-VS-5000 | $120 | $960 |
M-VS-20K | $120 | $960 |
M-PEG-SH: Methoxy PEG Thiol, MW 5000, MW 20000
M-PEG-SH reacts with the thiol groups on cystein side chains in proteins and peptides to generates a disulfide-bridged polymer conjugate. Substitution of M-PEG-SH is 90% or greater. Purity of M-SH-PEG is 90% or greater.
| Item Number | Price for 1.0g | Price for 10.0g |
M-SH-5000 | $120 | $960 |
M-SH-20K | $120 | $960 |
For N-Terminal PEGylation
M-PEG-ALD: Methoxy PEG Propionaldehyde, MW 5000, MW 20000, MW 30000, MW 40000
M-PEG-ALD preferably reacts with the N-terminal amine in biological active molecules to produce a stable amine linkage in the presence of a reducing reagent such as sodium cyanoborohydride. This aldehyde will couple with the N-terminal amine of the targeted molecules at pH 5-8. Substitution of M-PEG-ALD is 95% or greater. Purity of M-PEG-ALD is 95% or greater.
Item Number | Price for 1.0g | Price for 10.0g |
| M-ALD-5000 | $100 | $800 |
| M-ALD-20K | $100 | $800 |
| M-ALD-30K | $120 | $960 |
M-ALD-40K | $150 | $1200 |
Other Linear Methoxy PEG Derivative
M-NH2-PEG: Methoxy PEG Amine, HCl Salt, MW 2000, MW 5000, MW 20000, MW 30,000, MW 40,000
Substitution of M-NH2-20K is 95% or greater. The HCl Salt form provides stability in the solid form.
Item Number | Price for 1.0g | Price for 10.0g |
| M-NH2-2000 | $50 | $400 |
| M-NH2-5000 | $50 | $400 |
| M-NH2-20K | $50 | $400 |
| M-NH2-30K | $60 | $480 |
M-NH2-40K | $80 | $640 |
M-HZ-PEG: Methoxy PEG Hydrazide, MW 5000, MW 20000
Item Number | Price for 1.0g | Price for 10.0g |
| M-HZ-5000 | $100 | $800 |
| M-HZ-20K | $100 | $800 |
To order, please contact us at sales@jenkemusa.com
Other moleculars weights are available.
Quotations for bulk orders are available.
Prices are subject to change without notice.
Shipping and handling charge is not included in the price.
PEG Derivatives Custom Synthesis
JenKem has the expertise and experience on the synthesis of many kinds of special PEG derivatives. JenKem can design and synthesize to meet your special needs.