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PEG, PEG Derivatives, and PEGylation Services
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Branched PEG Derivatives for PEGylation

 

 

Branched PEG derivatives, also known as "Y-shaped" PEG derivatives, contain two linear methoxy PEG chain attached to a central core. The sterically bulky structure of these "Y-shaped" PEG derivatives will facilitate the single point attachment of the modified molecules.

The typical structure of "Y-shaped" branched PEG is as the following:

 



JenKem now provides the following three kinds of "Y-shaped" PEG derivatives. They are all JenKem's patented products. Y-NHS-40K can be used for amine PEGylation, Y-MAL-40K can be used for thiol PEGylation, and Y-ALD-40K (Y-AALD-40K and Y-PALD-40K) can be used for N-terminal PEGylation.

JenKem's "Y-shaped" PEG derivatives are chemically purified during synthesis so that they are low in polydispersity and are essentially free of activated bifunctional PEG side products.

 

 
For Amine PEGylation
Y-NHS-40K: Y-Shape PEG NHS Ester, MW 40000
 
 
This "Y-shape" NHS ester will react with the amino group of lysine(s) or the N-terminal amine in biological active molecules to produce a stable amide linkage(s). This NHS ester will couple with the targeted molecules at pH 7-8. The PEGylation reaction can be finished in about 1 hour.
Average molecular weight of this product is 40,000 Da. Substitution of this product is 95% or greater. This product is basically free of activated bifunctional PEG side products.
 
   

   

 Item NumberPrice for 1.0gPrice for 10.0g
Y-NHS-40K $150$1200 
 
 
 
For Thiol PEGylation
Y-MAL-40K: Y-Shape PEG Maleimide, MW 40000
 
This "Y-shape" maleimide will react with the thiol groups in biological active molecules to generates a stable 3-thiosuccinimidyl ether linkage. This maleimide will couple with the targeted molecules at pH 5.0-6.5 in the presence of other functional groups.
Average molecular weight of this product is 40,000 Da. Substitution of this product is 95% or greater. This product is basically free of activated bifunctional PEG side products.
 
   
 
 Item NumberPrice for 1.0g

Price for 10.0g

Y-MAL-40K $180$1440 
 
 
 
For N-Terminal PEGylation
The "Y-shape" aldehyde will preferably react with the N-terminal amine in biological active molecules to produce a stable amine linkage in the presence of a reducing reagent such as sodium cyanoborohydride. This aldehyde will couple with the N-terminal amine of the targeted molecules at pH 5-8.
Average molecular weight of this product is 40,000 Da. Substitution of this product is 95% or greater. This product is basically free of activated bifunctional PEG side products.
 
We now provide the following two kinds of Y-shape PEG Aldehyde
 
Y-AALD-40K: Y-shape PEG Acetaldehyde, MW 40000
 
 
 
 Item NumberPrice for 1.0g

Price for 10.0g

Y-AALD-40K $180$1440 

 

                        

 

 

 

 

 

Y-PALD-40K: Y-shape PEG Propionaldehyde, MW 40000
 
 
 
 Item NumberPrice for 1.0g

Price for 10.0g

Y-PALD-40K $180$1440 

 

                        

 

 

 

 

 
 
 
 
 
Complete products list

JenKem Product List.pdf

 

 

 

Storage and Handling Conditions for PEGs and PEG Derivatives

 

To order, please contact us at sales@jenkemusa.com

Quotations for bulk orders are available. 

Prices are subject to change without notice.

Shipping and handling charge is not included in the price.

 
 
 
PEG Derivatives Custom Synthesis
 
JenKem has the expertise and experience on the synthesis of many kinds of special PEG derivativves. JenKem can design and synthesize to meet your special needs.
 
Please contact JenKem USA at tech@jenkemusa.com for details.