Branched PEG Derivatives for PEGylation
Branched PEG derivatives, also known as "Y-shaped" PEG derivatives, contain two linear methoxy PEG chain attached to a central core. The sterically bulky structure of these "Y-shaped" PEG derivatives will facilitate the single point attachment of the modified molecules.
The typical structure of "Y-shaped" branched PEG is as the following:
JenKem now provides the following three kinds of "Y-shaped" PEG derivatives. They are all JenKem's patented products. Y-NHS-40K can be used for amine PEGylation, Y-MAL-40K can be used for thiol PEGylation, and Y-ALD-40K (Y-AALD-40K and Y-PALD-40K) can be used for N-terminal PEGylation.
JenKem's "Y-shaped" PEG derivatives are chemically purified during synthesis so that they are low in polydispersity and are essentially free of activated bifunctional PEG side products.